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Neurogenetics & Cancer Genetics

 

The study of variation within the genome allows to determine the predisposition to diferent diseases, Alzheimer, Parkinson, hereditary prion diseases, etc. 

The aim of Cancer Genetics is to study the genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. 

BIOMICs focuses on new discoveries that impact on the diagnosis and treatment of these diseases.

Publications (last 10 years):

1. Alegria-Lertxundi, I., Aguirre, C., Bujanda, L., Fernández, FJ., Polo, F., Ordovás, JM., Etxezarraga, MC., Zabalza, I., Larzabal, M., Portillo, I., de Pancorbo, MM., Palencia-Madrid, L., Garcia-Etxebarria, K., Rocandio, AM., Arroyo-Izaga, M. (2020). Gene-Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case-Control Study in the Basque Country. Nutrients, 12(8), 2362. https://doi.org/10.3390/nu12082362

 

2. Palencia-Madrid, L., Sánchez-Valle, R., Fernández de Retana, I., Borrego, S., Grau-Rivera, O., Reñé, R., Hernández, I., Almenar, C., Rossi, G., Caroppo, P., Redaelli, V., Le Ber, I., Camuzat, A., Brice, A., Antonell, A., Balasa, M., Gelpi, E., Lladó, A., de Pancorbo, MM. (2019). A unique common ancestor introduced P301L mutation in MAPT gene in frontotemporal dementia patients from Barcelona (Baix Llobregat, Spain). Neurobiology of Aging, 84, 236.e9–236.e15. https://doi.org/10.1016/j.neurobiolaging.2019.08.015

 

3. Alegria-Lertxundi, I., Aguirre, C., Bujanda, L., Fernández, FJ., Polo, F., Ordovás, JM., Etxezarraga, MC., Zabalza, I., Larzabal, M., Portillo, I., de Pancorbo, MM., Palencia-Madrid, L., Rocandio, AM., Arroyo-Izaga, M. (2019). Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population. PloS One, 14(12), e0225779. https://doi.org/10.1371/journal.pone.0225779

 

4. Moreno-Grau, S., de Rojas, I., Hernández, I., Quintela, I., Montrreal, L., Alegret, M., Hernández-Olasagarre, B., Madrid, L., González-Perez, A., Maroñas, O., Rosende-Roca, M., Mauleón, A., Vargas, L., Lafuente, A., Abdelnour, C., Rodríguez-Gómez, O., Gil, S., Santos-Santos, MÁ., Espinosa, A., Ortega, G., Sanabria, Á., Pérez-Cordón, A., Cañabate, P., Moreno, M., Preckler, S., Ruiz, S., Aguilera, N., Pineda, JA., Macías, J., Alarcón-Martín, E.,  Sotolongo-Grau, O., GR@ACE consortium, DEGESCO consortium, Alzheimer's Disease Neuroimaging Initiative, Marquié, M., Monté-Rubio, G., Valero, S., Benaque, A., Clarimón,  J., Bullido, MJ., García-Ribas, G., Pástor, P., Sánchez-Juan, P., Álvarez, V., Piñol-Ripoll,  G., García-Alberca, JM., Royo, JL., Franco, E., Mir, P., Calero, M., Medina, M., Rábano, A., Ávila, J., Antúnez, C., Real, LM., Orellana, A., Carracedo, Á., Sáez, ME., Tárraga, L., Boada, M., Ruiz, A. (2019). Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. Alzheimer's & Dementia: the journal of the Alzheimer's Association, 15(10), 1333–1347. https://doi.org/10.1016/j.jalz.2019.06.4950

 

5. Ruiz, B., Aguirre, U., Estany-Gestal, A., Rodella, L., Ruiz, P., Figueiras, A., Carvajal, A., Ibáñez, L., Conforti, A., de Pancorbo, MM., Vidal, X., Martin, LH., Aguirre, C. (2018). Only full adherence to proton pump inhibitors protects against drug-induced upper gastrointestinal bleeding. European Journal of Clinical Pharmacology, 74(11), 1503–1511. https://doi.org/10.1007/s00228-018-2523-4

 

6. Alegria-Lertxundi, I., Alvarez, M., Rocandio, AM., de Pancorbo, MM., Arroyo-Izaga, M. (2016). Nutritional Adequacy and Diet Quality in Colorectal Cancer Patients Postsurgery: A Pilot Study. Nutrition and Cancer, 68(4), 577–588. https://doi.org/10.1080/01635581.2016.1158299

 

7. Figueiras, A., Estany-Gestal, A., Aguirre, C., Ruiz, B., Vidal, X., Carvajal, A., Salado, I., Salgado-Barreira, A., Rodella, L., Moretti, U., Ibáñez, L., EMPHOGEN group. (2016). CYP2C9 variants as a risk modifier of NSAID-related gastrointestinal bleeding: a case-control study. Pharmacogenetics and Genomics, 26(2), 66–73. https://doi.org/10.1097/FPC.0000000000000186

 

8. Pastor, P., Moreno, F., Clarimón, J., Ruiz, A., Combarros, O., Calero, M., López de Munain, A., Bullido, MJ., de Pancorbo, MM., Carro, E., Antonell, A., Coto, E., Ortega-Cubero, S., Hernandez, I., Tárraga, L., Boada, M., Lleó, A., Dols-Icardo, O., Kulisevsky, J., Vázquez-Higuera, JL., Infante, J., Rábano, A., Fernández-Blázquez, MÁ., Valentí, M., Indakoetxea, B., Barandiarán, M., Gorostidi, A., Frank-García, A., Sastre, I., Lorenzo, E., Pastor, MA., Elcoroaristizabal, X., Lennarz, M., Maier, W., Rámirez, A., Serrano-Ríos, M., Lee, SE., Sánchez-Juan, P., Dementia Genetic Spanish Consortium (DEGESCO). (2016). MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium. Journal of Alzheimer's Disease, 49(2), 343–352. https://doi.org/10.3233/JAD-150555

 

9. Celorrio, D., Muñoz, X., Amiano, P., Dorronsoro, M., Bujanda, L., Sánchez, MJ., Molina-Montes, E., Navarro, C., Chirlaque, MD., MaríaHuerta, J., Ardanaz, E., Barricarte, A., Rodriguez, L., Duell, EJ., Hijona, E., Herreros-Villanueva, M., Sala, N., Alfonso-Sánchez, MA., de Pancorbo, MM. (2016). Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. Alcohol and Alcoholism (Oxford, Oxfordshire), 51(3), 258–267. https://doi.org/10.1093/alcalc/agv114

 

10. Gamarra, D., Elcoroaristizabal, X., Fernández-Martínez, M., de Pancorbo, MM. (2015). Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer's Disease in Carriers of the APOEε4 Allele. Disease Markers, 2015, 746329. https://doi.org/10.1155/2015/746329

 

11. Bediaga, NG., Aznar, JM., Elcoroaristizabal, X., Albóniga, O., Gómez-Busto, F., Artaza Artabe, I., Rocandio, A., de Pancorbo, MM. (2015). Associations between STR autosomal markers and longevity. Age (Dordrecht, Netherlands), 37(5), 95. https://doi.org/10.1007/s11357-015-9818-5

 

12. Bediaga, NG., Marichalar-Mendia, X., Rey-Barja, N., Setien-Olarra, A., Gonzalez-Garcia, JA., de Pancorbo, MM., Aguirre-Urizar, JM., Acha-Sagredo, A. (2015). Polymorphisms in alcohol and tobacco metabolism genes in head and neck cancer in the Basque Country. Journal of Oral Pathology & Medicine, 44(10), 769–775. https://doi.org/10.1111/jop.12305

 

13. Ruiz, A., Dols-Icardo, O., Bullido, MJ., Pastor, P., Rodríguez-Rodríguez, E., López de Munain, A., de Pancorbo, MM., Pérez-Tur, J., Alvarez, V., Antonell, A., López-Arrieta, J., Hernández, I., Tárraga, L., Boada, M., Lleó, A., Blesa, R., Frank-García, A., Sastre, I., Razquin, C., Ortega-Cubero, S., Lorenzo, E., Sánchez-Juan, P., Combarros, O., Moreno, F., Gorostidi, A., Elcoroaristizabal, X., Baquero, M., Coto, E., Sánchez-Valle, R., Clarimón, J., dementia genetic Spanish consortium (DEGESCO). (2014). Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia. Neurobiology of Aging, 35(2), 444.e1–444.e4444. https://doi.org/10.1016/j.neurobiolaging.2013.08.011

 

14. Bediaga, NG., Marichalar-Mendia, X., Aguirre-Urizar, JM., Calvo, B., Echebarria-Goicouria, MA., de Pancorbo, MM., Acha-Sagredo, A. (2014). Global DNA methylation: uncommon event in oral lichenoid disease. Oral Diseases, 20(8), 821–826. https://doi.org/10.1111/odi.12243

 

15. Ordoñana, JR., Rebollo-Mesa, I., Carrillo, E., Colodro-Conde, L., García-Palomo, FJ., González-Javier, F., Sánchez-Romera, JF., Aznar Oviedo, JM., de Pancorbo, MM., Pérez-Riquelme, F. (2013). The Murcia Twin Registry: a population-based registry of adult multiples in Spain. Twin Research and Human Genetics, 16(1), 302–306. https://doi.org/10.1017/thg.2012.66

 

16. Celorrio, D., Bujanda, L., Caso, C., Landabaso, M., Oria, JC., Ogando, J., de Pancorbo, MM. (2012). A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain. Alcohol (Fayetteville, N.Y.), 46(5), 427–431. https://doi.org/10.1016/j.alcohol.2012.03.003

 

17. Elcoroaristizabal Martín, X., Fernández Martínez, M., Galdos Alcelay, L., Molano Salazar, A., Bereincua Gandarias, R., Inglés Borda, S., Gómez Busto, F., Uterga Valiente, JM., Indakoetxea Juanbeltz, B., Gómez Beldarraín, MA., de Pancorbo, MM. (2011). Progression from amnesic mild cognitive impairment to Alzheimer's disease: ESR1 and ESR2 polymorphisms and APOE gene. Dementia and Geriatric Cognitive Disorders, 32(5), 332–341. https://doi.org/10.1159/000335541

 

18. Elcoroaristizabal Martín, X., Gómez Busto, F., González Fernández, MC., de Pancorbo, MM. (2011). Papel de la genética en la etiología de las sinucleinopatías [Role of genetics in the etiology of synucleinopathies]. Revista Española de Geriatria y Gerontologia, 46 Suppl 1, 3–11. https://doi.org/10.1016/j.regg.2011.10.002

 

19. Celorrio, D., Bujanda, L., Chbel, F., Sánchez, D., Martinez-Jarreta, B., de Pancorbo, MM. (2011). Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador. Alcoholism, Clinical and Experimental Research, 35(5), 879–884. https://doi.org/10.1111/j.1530-0277.2010.01418.x

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Congress contributions (last 10 years):

24ª Reunión anual Asociación Española de Gastroenterología (AEG)

Virtual

1-4 June 2021

Chao-Seijo, B., Alegria-Lertxundi, I., de Pancorbo, MM., Bujanda, L., Aguirre, C., Fernández, FJ., Polo, F., Portillo, I., Palencia-Madrid, L., Etxezarraga, MC., Saiz, A., Segues, NM., Portugal, V., Barrero, M., Rocandio, AM., Arroyo-Izaga, M.

Pro- y antioxidantes relacionados con estilos de vida y el riesgo de cáncer colorrectal: estudio de casos y controles en el País Vasco.

I Jornada Multidisciplinar de Cuidados del País Vasco

Vitoria-Gasteiz, Spain

2-4 October 2019

Uriarte, MA., Fernández, J., Calvo, MI., Martin, MB., Hernández, A., Gamarra, D.

Correlación del MoCA test (Montreal Cognitive Assessment test) con la edad y diagnostico clínico en pacientes con enfermedad mental en el Hospital Psiquiátrico de Álava.

Poster

XXXV Congreso Nacional de Enfermería de Salud Mental

Santiago de Compostela, Spain

21-23 March 2018

Gamarra, M., Ayuso. L., Fernández, D., Gamarra, D., Aguado, M.

Trastornos de conducta alimenticia en mujeres deportistas
.

Poster

 

Aguado, M., Gamarra, D., Gamarra, M., Ayuso, L., Fernández, D.

La paradoja de Cotard. A propósito de un caso clínico
.

Poster

 

Ayuso, L., Fernández, D., Gamarra, D., Aguado, M., Gamarra, M.

Programa psicoeducativo para el manejo de la sobrecarga en el cuidador del paciente con trastorno mental grave en una unidad de rehabilitación intensive.

Poster

10th International Conference on Frontotemporal Dementias

Munich, Germany

31 August - 2 September 2016

Palencia-Madrid, L., Borrego, S., Grau-Rivera, O., Reñe, R., Hernandez, I., Almenar, C., Antonell, A., Balasa, M., Llado, A., Gelpi, E., de Pancorbo, MM., Sanchez-Valle, R.

Founder effect of P301L MAPT mutation in families withFTD in Baix Llobregat County (Barcelona, Spain).

Poster

2nd Barcelona International Conference on Healthy Ageing

Barcelona, Spain

19-20 June 2014

de Pancorbo, MM.

Genetics of ageing.

Invited speaker

 

Constitución del Grupo Español para el Estudio de Centenarios

Valencia, Spain

17 May 2013

de Pancorbo, MM.

Marcadores genéticos en longevidad y demencia.

Invited speaker

 

7th Congress of EUGMS (European Union Geriatric Medicine Society), 53  Congress of the SEGG (Sociedad Española de Geriatría y Gerontología) and 32  Congress of the SAGG (Sociedad Andaluza de Geriatría y Gerontología)

Málaga, Spain

28-30 September 2011

Gómez Busto, F., Elcoroaristizabal Martín, X., UG, E., de Pancorbo, MM.

Correlation between cognitive tests and the diagnosis of Alzheimer’s disease in a group of autonomous residents.

 

Conferencia “Consulta Preconcepcional”

Bilbao, Spain

18 October 2011

de Pancorbo, MM.

Invited speaker

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